我的醣科學研究之路

2016年1月,美國總統歐巴馬在國情咨文中強調美國應該要領先世界,本著挑戰不可能任務的精神,發展根治癌症的方法,就是目前的「國家癌症登月計畫」(National Cancer Moonshot)。台灣由於在癌症基因體研究已累積深厚的資源與成果,是美國癌症研究院邀請參與的國家之一。我所致力研究的醣分子不僅廣泛存在於細胞中,也和許多疾病有關,意外引導我走向以醣科技發展治癌及傳染性疾病新藥的開發。

撰文/翁啟惠

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醣化酵素互動新發現

決定醣蛋白上醣分子的組成、功能與疾病的關係

中央研究院基因體研究中心特聘研究員翁啟惠院士研究團隊,關於探究與癌細胞惡化有密切關聯的酵素FUT8之論文,已於7月5日發表於《美國化學會期刊》 (Journal of the American Chemical Society)。此研究結果不但確定FUT8對醣分子有選擇性,更進一步配合質譜研究,釐清其於細胞內醣化的步驟,並發現新的醣化調控機制,這項成果對於蛋白質醣化的研究及之後蛋白藥物的研發,均具有影響力。

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The Interplay of Glycosyltransferases Shapes the Structures of Glycans

Their Function and Disease State

Dr. Chi-Huey Wong, Distinguished Research Fellow at the Genomics Research Center (GRC), and his team have recently published a report that increases understanding of the substrate specificity of an enzyme called fucosyltransferase 8 (FUT8). FUT8 is the only enzyme to catalyze core fucosylation of N-glycans on glycoproteins in mammalian cells. This research furthers our understanding of the important biological process of glycosylation, and has potential to be applied to explore new glycan markers for diseases or cancers and/or lead to the development of better glycoprotein pharmaceuticals such as antibody drugs. The research was published in JACS, the Journal of the American Chemical Society, on July 5.

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